15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl) -OH

White crystalline ntụ ntụ;Na-adịghị edozi na mmiri na mmanụ ala ether, soluble na ethyl acetate na methanol;mp bụ 115-116 ℃;Ntụgharị pụrụ iche [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
A na-eji polypeptide synthesis, dị ka ihe nchebe amino acid monomer.
O-benzyl-l-threonine kwụsịrị na ngwọta dioxane na acylated na tert-butylcarbonyl azide iji nweta ngwaahịa crude, nke ethyl acetate wepụtara na pH nke 9-10 wee megharịa ya.
Akụkụ na-arụ ọrụ nke thymic oietin Ⅱ nke ihe nzuzo thymus.Thymoietin II bụ otu polypeptide dịpụrụ adịpụ na homonụ thymus.Ọ bụ amino acid 49 mejupụtara ya, na iberibe peptide yinye nke amino acid 5 mejupụtara nwere otu ọrụ physiological niile dị ka thymoietin II.Ya mere, a na-akpọ iberibe pentapeptide a thymus pentapeptide.Ocha ma ọ bụ ntụ ntụ akpọnwụrụ akpọnwụ.
Otu n'ime ọrụ thymus pentapeptide bụ ịkpata ọdịiche nke cell T.Ọ nwere ike họrọ ịkpalite mgbanwe nke sel Thy-1-prothorax n'ime sel Thy-1+ T.A na-agbazi ọdịiche nke cell T site na ụba caMP intracellular.Ọrụ ọzọ bụ isi nke thymus pentapeptides bụ ijikọ ndị na-anabata ya nke mkpụrụ ndụ ọbara T tozuru oke, na-abawanye ọkwa cAMP intracellular, wee mee ka usoro mmeghachi omume intracellular, nke bụkwa ntọala nke ọrụ immunomodulatory ya.N'ọnọdụ ahụ nkịtị, thymus pentapeptide gosipụtara mmetụta na-akpali akpali, nke nwere ike ịbawanye ọnụ ọgụgụ nhazi nke E rosette na ọnụego mgbanwe nke lymphocytes splenic, kwalite ọkwa dị iche iche nke nzaghachi mgbochi mbụ ma ọ bụ nke abụọ, yana ịbawanye ọnụ ọgụgụ nke ụdị IgM na IgG ma ọ bụ Ụdị mgbochi IgA na-akpụ mkpụrụ ndụ.Thymus pentapeptide nwekwara ike ịkwalite ọrụ phagocytosis nke macrophages, na-abawanye ọrụ enzyme na phagocytosis nke neutrophils polymorphonuclear, na-abawanye ọdịnaya mgbochi na-ekesa, na ịkwalite ọrụ mgbochi nke mkpụrụ ndụ ọbara uhie.Thymus pentapeptide nwere ike ịgbalite CD4 na CD8 mkpụrụ ndụ dị mma, nke mere na mkpụrụ ndụ Tc kpọmkwem nwere ike ịnọgide na-adị ogologo ndụ, ma nwee ike ịgbalite mkpụrụ ndụ Th ma mee ka ọrụ nke mkpụrụ ndụ Ts rụọ ọrụ.Mmetụta mgbochi ọrịa na ọgwụgwọ nke thymus pentapeptide metụtara nkwalite ya nke ọrụ cell TC.Obere thymus pentapeptide kwesịrị ekwesị nwere ike ịbawanye mmepụta nke interferon na mgbochi ọrịa.Inweta na ịkwalite T cell iche na maturation;CD4/CD8 na-adịkarị ka ọ dị mma site n'ịhazi oke nke T lymphocyte subsets;kwalite ọrụ phagocytosis nke macrophages;Kwalite ọrụ mgbochi ọrịa ọbara ọbara uhie;Mụbaa ọrụ nke mkpụrụ ndụ egbu egbu eke;Mmụba ọkwa nke mmepụta interleukin-2 na nkwupụta nnabata;Mee ka mmepụta nke γ interferon dị na sel mononuclear dị n'akụkụ ọbara;Kwalite ọrụ SOD na serum.
Enwere ike iji ya na ndị ọrịa tumor na-adịghị mma nwere ọrụ mgbochi ọrịa mgbe usoro redio na chemotherapy gasịrị.Ọgwụgwọ ịba ọcha n'anya B;Nnukwu ọrụ ịwa ahụ na ọrịa siri ike;Ọrịa autoimmune dị ka ọrịa ogbu na nkwonkwo, lupus erythematosus;Ụdị ọrịa shuga mellitus nke abụọ, ọrịa menopause;Onye na-arụ ọrụ mgbochi ọrịa adịghị ike.