22254-24-6 8-Isopropylatropinium bromide

A na-akpọkwa Ipratropium bromide dị ka Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide.Ọ bụ ntụ ntụ kristal na-acha ọcha nke nwere uto ilu.Ebe mgbaze 232 ℃-233 ℃.Soluble na mmiri, ubé soluble na ethanol, insoluble na ndị ọzọ organic solvents.Aha kemịkal: Brominated α-(hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Ọ bụ ọgwụ anticholinergic, nke nwere mmetụta ntụrụndụ siri ike na akwara dị nro nke bronchial na mmetụta antiasthmatic na ọrịa na-adịghị ala ala obstructive pulmonary.Mmetụta ya doro anya, mmetụta ngwa ngwa na ogologo oge.Ipratropium bromide na-ejikwa secretion nke mucus glands ma na-eme ka mmegharị ciliary dịkwuo mma, si otú a na-ebelata nkwụsị sputum iji meziwanye ikuku.Ka ọ dị ugbu a, mbelata sputum na-ebelatakwa bronchospasm nke mgbakasị ahụ na-akpata.Maka mgbochi na ọgwụgwọ nke ụkwara ume ọkụ na ụkwara ume ọkụ na-adịghị ala ala, karịsịa maka ndị ọrịa na-enweghị ike ịnagide iji β-agonist muscle tremor, tachycardia.Enwere ike iji ngwaahịa a na-ejikọta ya na beta-agonists iji kwalite ịdị irè nke ibe ya, dị ka ijikọta na finoterol na-emepụta ikuku aerosol (BERODU-AL) maka ụkwara ume ọkụ, bronchitis na-adịghị ala ala na emphysema.E jiri ya tụnyere β-adrenergic receptor stimulants (dịka ọmụmaatụ, isopropyl epinephrine), ngwaahịa a nwere obere mmetụta dị n'akụkụ obi, ma e jiri ya tụnyere β2-receptor stimulants (dịka, Suquanling), ngwaahịa a nwere mmetụta nchịkwa siri ike na olu phlegm.
fesa ikuru ume.40 ~ 80μg otu ugboro, 2 ~ 4 ugboro n'ụbọchị.Mgbe ị na-eji ya, buru ụzọ wepụ okpu mkpuchi mkpuchi, tinye anya mkpuchi mkpuchi obe na nozzle, tụgharịa karama ahụ ihu, tinye mkpuchi mkpuchi n'ọnụ, mee n'akpịrị, gbanye gas n'otu oge ahụ, pịa oghere ahụ. na valvụ, kukuo mmiri mmiri, jide ume gị nwa oge.Tinyegharịa ọnyà dị n'elu otu ugboro ma ọ dị mkpa.Aerosol: 0.025% ngwọta.Mbadamba ụrọ: 10mg / mbadamba.
Enwere ike ịgwọ nsị anticholinergic siri ike na ndị na-egbochi cholinesterase.
Mmeghachi omume ọjọọ nke ipratropium bromide yiri atropine, nke nwere ike ime ka obi mgbawa, isi ọwụwa, dizziness, ụjọ, ọgbụgbọ, vomiting, mgbu afọ, ịma jijiji, ọhụụ na-adịghị mma, ọnụ nkụ, ụkwara, dysuria, mmụba nke mgbaàmà iku ume na ọkụ ọkụ.
Ipratropium bromide bụ onye na-emegide muscarinic, bronchodilator, na nnu isopropyl nke AtropineN.
Ipratropiumbromide na Formoterol jikọtara akụkụ iji chebe ngụgụ site na mbufụt na-adịghị ala ala ma gbasaa ngụgụ, na-ebelata neutrophils site na igbochi ọrụ site na MMP-9.Ipratropiumbromide (1nM) na-abawanye ụba nke calcium bromide, belata mgbasa ozi na-aga n'ihu na mmụba annexin-V.Mgbe ọgwụgwọ Ipratropiumbromide gasịrị, hemolysis mụbara ntakịrị mana nke ukwuu.Ipratropiumbromide na-akpata ọnwụ nke mkpụrụ ndụ ọbara uhie ma ọ bụ eryptosis, nke bụ isi n'ihi mkpali calcium.
Ipratropium dry powder inhalation (DPI) bụ bronchodilator dị irè n'ịnyịnya ezumike na dose nke 2400 mg / ịnyịnya, na-enwe mmetụta dị nta na elu ụgbọ elu caliber n'oge mgbake.N'ime oke ndị a na-agwọ cadmium, Ipratropium na-ebelata nrịanrịa nke mkpụrụ ndụ mkpali nke parenchymal ma hụ ọnya ngụgụ jikọtara ọnụ.Ipratropium na-echebe akụkụ nke ngụgụ site na mbufụt site na ibelata ntinye neutrophil.Na guinea pig tracheal muscle ire ụtọ, Ipratropium bụ onye na-emegide ya na-egbochi onye na-anabata ihe mgbochi muscarin nke na-anabata nke akwara parasympathetic nku ume.E gosikwara na Ipratropium bụ onye na-emegide ndị na-emegide muscarinic na-egbochi ndị na-anabata ya.Ipratropium na-ebelata mgbanwe kachasị na nrụgide obi ma na-abawanye nnabata ike (Cdyn) na respiration tidal (incremental Pplmax) na nguzogide pulmonary (RL) na ịnyịnya.