nke China 87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE Onye nrụpụta na ụlọ ọrụ |Jiayinglai
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87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE

87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE egosipụtara
  • 87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE
  • 87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE
  • 87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE

87512-31-0 Fluorene methoxy carbonyl-L-ALANYL-L-ALANINE

Nkọwa dị mkpirikpi:

Ọdịdị kristal na-acha ọcha ruo na-acha ọcha ma ọ bụ ntụ ntụ kristal.
MF C21H22N2O5
MW 382.41
Ịdị ọcha 98+


Nkọwa ngwaahịa

Ọnọdụ njem&ụkpụrụ mbupu akwadoro:
?

Ọnọdụ nchekwa:
A na-ekpuchi ya na akọrọ, 2-8 ° C

Ọnụ ahịa kacha nta:
Mkparịta ụka

Asambodo:
COA, HPLC, GC, HNMR, Assay, Ọdịnaya Mmiri (KF), TLC dị

D-Lys(tfa) -NCA (2)

Ụdị okwu

FMOC-ALA-ALA-OH;
Fmoc-L-Ala-L-Ala-OH;
(S)-2-((S) -2-(((9H-Fluoren-9-yl) methoxy) carbonyl) amino) propanamido) propanoic acid;
Fmoc-Ala-Ala-OH99%;
FMoc-Ala-Ala;
FMOC-ALA-ALA-OH;
FMOC-L-ALANYL-L-ALANINE;
FMoc-AA-OH;
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-alanine

Nkwakọ ngwaahịa n'ime

A na-ejikarị ha ebu ntụ ntụ.Ha nwekwara ike igbochi anwụ na mmiri ime ihe ọjọọ.

mpụta mbukota

Katọn ahụ siri ike nwere ike ichekwa ngwaahịa gị ka ọ ghara ịdaba na mmiri.

Ngwa

Ngwaahịa a bụ polypeptide nke amino acid 28 mejupụtara.Maka N - acetyl - L - silk amonia acyl - L - alfa amino amonia acyl - L - propylene amonia acyl - L - propylene amonia acyl - L - valerian ammonia acyl - L - alpha amino amonia acyl - L - Sue amonia acyl - L - waya amonia acyl - L - waya amonia acyl - L - alfa glutamine - L - ìhè dị iche iche amonia acyl - L - Sue amonia acyl - L - Sue amonia acyl - L - lai amonia acyl - L - alfa amino ammonia acyl - L - amonia acyl na-egbuke egbuke - L - lai amonia acyl - L - alfa - glutamine - L - lai amonia acyl - L - lai amonia acyl - L - alfa glutamine - L - valerian amonia acyl - L - valerian amonia acyl - L - alfa glutamine - L - alfa - glutamine - L - propylene amonia mmanya - L - alfa - glutamine - L - asparagine.Dabere na ngụkọta nke ihe anhydrous na acetic acid na-enweghị, usoro thymus nwere usoro (C129 H215 N33O55) kwesịrị ịbụ 95.0% ~ 105.0%.
Ngwaahịa a bụ ọcha ma ọ bụ ọcha ntụ ntụ ma ọ bụ na-adịghị mma.
A na-agbaze ngwaahịa a na trifluoroacetic acid, ntakịrị soluble n'ime mmiri, enweghị ike ime na acetonitrile, ether na trichloromethane.
Were ngwaahịa a, tụọ ya nke ọma, tinye 0.02mol/L phosphate buffer solution (pH 7.0) (were 2.72g potassium dihydrogen phosphate, tinye 0.1mol/L sodium hydroxide solution 116.4ml ka igbari, gbanye mmiri na 1000ml) ngwọta nwere ihe dị ka 5mg na 1 ml ọ bụla.Ekpebiri dịka iwu siri dị (Ihe mgbakwunye ⅥE nke akụkụ II nke Pharmacopoeia, mbipụta 2010), curl a kapịrị ọnụ kwesịrị ịbụ -100.0° ruo -110.0° dabere na ngụkọ nke ihe anhydrous na acetic acid na-enweghị.
Usoro nke ngwaahịa a na-agwọ ọrịa ịba ọcha n'anya B na ịkwalite mmeghachi omume nke usoro ahụ ji alụso ọrịa ọgụ akọwabeghị nke ọma.Ọnụ ọgụgụ nke nnwale in vitro egosila na ngwaahịa a nwere ike ịkwalite ntozu nke T lymphocytes site n'ịkpali mitogen nke lymphocytes ọbara dị n'akụkụ, na-abawanye ọkwa nke interferon α, interferon γ, interleukin 2, interleukin 3 na ihe ndị ọzọ lymphatic zoro ezo site na mkpụrụ ndụ T. mgbe arụ ọrụ nke antigen ma ọ bụ mitogen, ma n'otu oge ahụ na-abawanye ọkwa nke ndị na-anabata lymphofactor n'elu sel T.Ọ nwekwara ike welie nzaghachi nke allogeneic na autologous mmadụ agwakọta lymphocytes site ebighị nke CD4 cell.Ngwaahịa a nwere ike ịbawanye mkpokọta nke mkpụrụ ndụ tupu NK, yana interferon nwere ike ịbawanye cytotoxicity ha.Nnwale vivo gosipụtara na ngwaahịa a nwere ike ịbawanye ọkwa ọkwa nke interleukin-2 nnabata yana ọkwa nzuzo nke interleukin-2 na lymphocytes òké mgbe cancanadin A gbalite.

ngwaahịa ndị metụtara ya

Gly-Ala-Ome.hcl Fmoc-L-Ala-OH β-Ala-Ome.HCl L-Ala-Phe-OH
Gly-Gly-Ala-Ome.hcl Fmoc-DL-Ala HL-Ala-Ome.Hcl L-Ala-Leu-OH
L-ALA Fmoc-D-Ala-OH β-Ala-Otbu.HCl L-Ala-Pro-OH
DL-ALA Fmoc-β-Ala-OH DL-Ala-Otbu.Hcl DL-Ala-DL-Val
H-Ala-ọl Fmoc-LN-Me-Ala-OH L-Ala-NH2.HCl Ala-Gly-Ome.hcl
β-Ala-ọl Fmoc-N-Me-D-Ala-OH HD-Ala-NH2·HCl L-Ala-Ala-Obzl.HCl
D-ALA Fmoc-Ala-Cl HD-Ala-NH2 D-Ala-D-Ala-Ome.Hcl
H-β-Ala-OH Fmoc-L-Ala-Ol Ac-L-Ala-NH2 H-Ala-Ala-Otbu.HCL
HN-Me-L-Ala-OH fmoc-β-Ala-NH2 Ac-D-Ala-NH2 Boc-Ala-Phe-OH
HN-Me-D-Ala-OH Fmoc-Ala-Ome AC-D, L-Ala-OH Boc-L-Ala-Leu
L-Ala-NCA Fmoc-Ala-Osu Ac-D-Ala-OH Boc-ALA-Val-OH
D-Ala-NCA fmoc-β-Ala-osu AC-L-Ala-OH Boc-Ala-Pro
L-Ala-nbu.hcl Cbz-L-Ala-OH AC-L-Ala-OME Boc-Ala-Gly-OH
L-Ala-Otbu Cbz-D-Ala-OH Pht-D-Ala Boc-Ala-Ala-OH
D-ALA-Oipr.HCL Cbz-N-Me-L-Ala-OH Pht-L-Ala Boc-Ala-Ala-Ome
D-Ala-Otbu.Hcl Cbz-N-Me-D-Ala-OH Boc-L-Ala-OH Boc-Ala-Ala-Obzl
N-Me-L-Ala-OMe Cbz-DL-Ala-OH Boc-D-Ala-OH Fmoc-Ala-pro
HD-Ala-OBzl·HCl Z-β-L-Ala-OH Boc-DL-Ala-OH Fmoc-Ala-gly-OH
β-Ala-Obzl.Tos Cbz-L-Ala-OL Boc-β-Ala-OH Fmoc-L-Ala-Ala-OH
H-Ala-OBzl·HCl Cbz-L-Ala-NH2 Boc-N-Me-Ala-OH Fmoc-β-Ala-D-phe
HL-Ala-OBzl.Tos-OH Cbz-L-Ala-Ome Boc-N-Me-DL-Ala-OH Fmoc-β-Ala-D-Tyr (Et)
HD-Ala-Oet.HCl Cbz-D-Ala-OMe Boc-N-Me-D-Ala-OH Cbz-Ala-Val-OH
HL-ALA-Oipr.HCL Cbz-Beta-Ala-Ome Boc-L-Ala-Ol Cbz-L-Ala-Ala-OH
N-Me-Ala-Otbu.Hcl Cbz-β-Ala-Otbu Boc-D-Ala-Ol Cbz-Ala-Pro-OH
HL-Ala-OtBu·HCl Cbz-L-Ala-Osu Boc-DL-Ala-Ol Cbz-L-Ala-Leu-OH
H-DL-Ala-OMe.HCl Cbz-Beta-Ala-OSU Boc-Ala-NH2 Cbz-L-Ala-Ala-Ome
β-Ala-Oet.HCl Ala-Ala-OH Boc-D-Ala-NH2 Ala-Ala-Ome.HCL
N-Me-L-Ala-Ome.hcl Ala-gly Boc-β-Ala-NH2 Val-Ala
HD-Ala-Ome.Hcl L-ALA-Val-OH Boc-D-4-Chloropheny (alanine) Boc-Ala-Pro
Boc-L-ALA-OBZL Boc-Leu-Ala Boc-D-3 (1-Naphthgl) -alanine Boc-Val-Ala
Boc-L-Ala-OSu Fmoc-leu-ala Boc-L-Ala-Ome Cbz-Val-Ala-OH
Boc-L-Beta-Ala-Osu Cbz-Leu-Ala-OH Boc-D-Ala-OMe Cbz-Val-Ala-Ome
Boc-D-Ala-OSu Ph-Ala Boc-L-Ala-Otbu Leu-Ala-OH
Fmoc-L-Ala-OH.H2O Boc-Phe-Ala-OH Z-Lys(boc)-Ala-Ala-OBzl HL-Thr-OBzl·oxalate
HL-Thr (Bzl)-OBzl.oxalate Cbz-Phe-Ala-OH  

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