China 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Manufacturer and Factory |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Nkọwa dị mkpirikpi:

Ọdịdị	kristal na-acha ọcha ruo na-acha ọcha ma ọ bụ ntụ ntụ kristal.
MF	C16H22N2O6
MW	338.36
Ịdị ọcha	98+

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Nkọwa ngwaahịa

Ọnọdụ njem&ụkpụrụ mbupu akwadoro:
site n'ikuku, site n'oké osimiri ma ọ bụ site na awara awara

Ọnọdụ nchekwa:
Emechiri ya na nkụ, Okpomọkụ ụlọ

Ọnụ ahịa kacha nta:
Mkparịta ụka

Asambodo:
COA, HPLC, GC, HNMR, Assay, Ọdịnaya Mmiri (KF), TLC dị

Ụdị okwu

(S) -ethyl 2- (tert-butoxycarbonylaMino) -3- (4-nitrophenyl) propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, ethyl ester

Nkwakọ ngwaahịa n'ime

A na-ejikarị ha ebu ntụ ntụ.Ha nwekwara ike igbochi anwụ na mmiri ime ihe ọjọọ.

mpụta mbukota

Katọn ahụ siri ike nwere ike ichekwa ngwaahịa gị ka ọ ghara ịdaba na mmiri.

Ngwa

Nidanib, ọ bụ kemịkalụ.Aha kemịkal 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland nke methyl] - 2 - oxygen -, methyl ester, (z) - Clinically, ngwaahịa a na-eji na-emeso idiopathic pulmonary fibrosis (IPF).
Nidanib amụla ndị ọrịa 1,529 nwere idiopathic pulmonary fibrosis (IPF) n'ọtụtụ ule ụlọ ọgwụ.Ihe nchekwa data ewepụtara dabere na ntụnyere ndị ọrịa 1061 nyere nidanib 150 mg ugboro abụọ kwa ụbọchị yana placebo n'ime usoro 52-izu abụọ nke 3, randomized, kpuru ìsì abụọ, ebe a na-achịkwa placebo (INPULSIS-1 na INPULSIS-2).Ihe omume ọjọọ kachasị ejikọta na iji nidanib gụnyere afọ ọsịsa, ọgbụgbọ na ọgbụgbọ, afọ mgbu, ọnwụ nke agụụ, ọnwụ dị arọ, na enzymes imeju dị elu.Biko rụtụ aka na [akpachara anya] maka njikwa mmeghachi omume ọjọọ kwekọrọ.Usoro nhazi akụkụ (SOC) nke MedDRA na-enye nchịkọta nke mmeghachi omume ọjọọ yana nhazi oge.
Nidanib bụ mkpụrụ maka P-gp (lee Pharmacokinetics).N'ime nyocha a kapịrị ọnụ nke mmekọrịta ọgwụ ọjọọ, njikwa mkpokọta ketoconazole, onye na-egbochi P-gp dị ike, na-abawanye ikpughe na nidanib ugboro 1.61 site na mpaghara n'okpuru usoro (AUC) na ugboro 1.83 site na ntinye uche kacha elu (Cmax).
N'ime ọmụmụ mmekọrịta ọgwụ na P-gp inducer rifampicin dị ike, ikpughe na nidanib gbadara ruo 50.3%, dịka atụpụtara site na mpaghara n'okpuru usoro (AUC), mgbe ejikọtara ya na rifampicin ma e jiri ya tụnyere Nidanib naanị.Site na ntinye uche kacha elu (Cmax), ọ gbadara ruo 60.3%.
Mgbe ejiri ya na ngwaahịa a, ndị na-egbochi P-gp siri ike (dịka, ketoconazole ma ọ bụ erythromycin) nwere ike ịbawanye ikpughe na nidanib.N'okwu ndị a, a ga-enyocha nnabata nke onye ọrịa na nidanib.Ijikwa mmeghachi omume ọjọọ nwere ike ịchọ nkwụsị, mbelata dose, ma ọ bụ ịkwụsị ọgwụgwọ na ngwaahịa a (lee [Ojiji na usoro onunu ogwu]).
P-gp nwere ike inducers (dịka, rifampicin, carbamazepine, phenytoin na St. John's wort) nwere ike ibelata ikpughe na nidanib.Nchikota ọzọ na enweghị ma ọ bụ ntakiri ntinye P-gp kwesịrị ịtụle.

ngwaahịa ndị metụtara ya

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny (alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Ph-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe (4-NO2) -OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe (4-NO2) .H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu) -Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Ty-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Nke kacha elu

1. R&D ọrụ dị
2. Onye nrụpụta akwụkwọ ikike ISO, nkwa dị mma
3.A zuru oke nke ọrụ ntinye aka n'oge mmepụta
4.High ọnụ ahịa dị irè
5.Quality akwụkwọ ikike nyere maka arịrịọ ndị ahịa
6.Great after-sales service, ịnọgide na-enwe mmekọrịta chiri anya na ndị ahịa
7.Full akụ iji nyere aka belata ụgwọ mbupu
8.Free sample nyere iji lelee àgwà tupu ịkwụ ụgwọ ọ bụla
9.Payment okwu mkparita uka
Ndị ahịa 10.Assit na-emekọ ihe na China