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340-90-9 N-Pht-Glu

340-90-9 N-Pht-Glu

Nkọwa dị mkpirikpi:

Ọdịdị Na-acha ọcha na-acha ọcha ntụ ntụ
MF C13H11NO6
MW 277.23
Ịdị ọcha 98+


Nkọwa ngwaahịa

Ọnọdụ njem
Nwere ike ịdị na okpomọkụ nkịtị

Kwado usoro mbupu
Site ikuku Site n'ala Site n'oké osimiri

Ọnọdụ nchekwa:
Debe n'ebe gbara ọchịchịrị, ikuku na-adịghị mma, okpomọkụ ụlọ

Ndụ nchekwa
Ihe dị ka afọ 2

Ọnụ ego kacha nta:
1kg (mkparịta ụka)

Asambodo:COA, ebe mgbaze, SpecificRotation [α]D20                      

Anyị ga-eziga data ọ bụla ịchọrọ.Ị nwere ike ịhụ data tupu dị ka ntụaka.

Maka ngwaahịa ahaziri ahazi, anyị na-eziga data kachasị ọhụrụ mgbe ha pụtachara.

D-Lys(tfa) -NCA (2)

Ụdị okwu

(2S) -2- (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl) pentanedioicacid;

n-phthalyl-l-glutamicacid;

N-PHTHALIMIDEL-GLUTAMINCACID;

N-PHTHALOYL-L-GLUTAMICACID;

PHTHALYL-L-GLUTAMICACID;

PHTHALOYL-L-GLUTAMICACID;

PHT-GLU-OH;

PHGA

Nkwakọ ngwaahịa n'ime

A na-ejikarị ha eme ihe maka ịkwakọba ntụ ntụ.Ọ dabere na ihe ndị ahịa chọrọ.Ya mere, gwa anyị ihe ị na-achọ tupu ịkwakọ ngwaahịa ma ọ bụrụ na ị nwere arịrịọ pụrụ iche.

Nkwakọ ngwaahịa dị n'ime 2
Nkwakọ ngwaahịa dị n'ime 1
Nkwakọ ngwaahịa dị n'ime 3

mpụta mbukota

1kg ruo 25kg Mbukota mpụta siri ike.Ọ na-esikwa ike ịkpụ na imebi.Ọ nwere ike ichekwa ngwaahịa gị nke ọma.

Mkpokọta mpụta 3
Mkpokọta mpụta 2
Nkwakọ ngwaahịa dị n'èzí 1

Ngwa

Enwere ike iji PHTHALYL-L-GLUTAMIC ACID mee (R)-(+) THALIDOMIDE.Ọ bụ glutamic acid ewepụtara na-enweghị mmetụta ọgwụgwọ na ekpenta, a na-ejikwa ya na ọgwụ antileprosy iji belata mmeghachi omume ekpenta yana ịgwọ ụdị mmeghachi omume ekpenta dị iche iche, dị ka nnukwu lymph nodes, erythema nodosum, ahụ ọkụ, arthralgia na neuralgia na-arụ ọrụ nke ọma. .
Mmetụta immunomodulatory nke thalidomide dịgasị iche iche dịka ọnọdụ nnwale siri dị, na-enwe nsonaazụ na-emegiderịta mgbe ụfọdụ.Mmetụta na lymphocytes gụnyere mbelata nke sel CD4+ na mkpali nke sel CD8+, na-ebute mbelata na oke CD48.
Na mgbakwunye, thalidomide na-egosi na ọ na-ebute mgbanwe site na Th1 gaa na nzaghachi Th2.
Cyclosporine na thalidomide mere n'ụdị abụọ nke T-lymphocytes, Th1 na Th2, na Thd achọpụtara na-akpalite ma kwalite njikọ nke IL-4 na IL-5, na-egbochi njikọ nke interferon gamma (IFN-γ) site na phytohemagglutinin-kpaliri mmadụ. monocytes ọbara dị n'akụkụ, ma belata ọkwa nke TNF-α, IL-6, na IL-10 mRNA, na-enweghị mmetụta na ọkwa IL-12 na IFN-γ mRNA enweghị mmetụta ọ bụla.

ngwaahịa ndị metụtara ya

HL-Glu-OH HD-Glu-OH DL-Glu-OH Boc-L-Glu-OH
Boc-D-Glu-OH Boc-Glu (trt) - OH Fmoc-L-Glu-OH Fmoc-D-Glu-OH
Cbz-L-Glu-OH Cbz-D-Glu-OH Cbz-L-Glu-Otbu Cbz-L-Glu(Oet)-OH

Gịnị mere Họrọ Anyị

1. Banyere MOQ: Anyị nwere ike ịhazigharị ya dịka ihe ị chọrọ.
2. Banyere ihe atụ: Ihe nlele ahụ chọrọ ego nlele, nke nwere ike ibu ibu iji nakọta ma ọ bụ ị nwere ike ịkwụ anyị ụgwọ tupu oge eruo.
3. Ụlọ ihe omumu ihe, enwere ike ịhazi ya dị ka ọnụ ọgụgụ nke ụdị.
4. Anyị na-enye ọrụ kacha mma.Otu ndị ahịa nwere ahụmahụ na-arụ ọrụ maka gị.
5. Banyere mgbanwe: Biko email ma ọ bụ kpaara m nkata na gị mma.


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