China 200124-22-7 Tert-butoxycarbonyl-arginine(Pbf) -OH Onye nrụpụta na ụlọ ọrụ |Jiayinglai

200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH

Nkọwa dị mkpirikpi:

Ọdịdị	kristal na-acha ọcha ruo na-acha ọcha ma ọ bụ ntụ ntụ kristal.
MF	C24H38N4O7S
MW	526.65
Ịdị ọcha	98+

Zitere anyị email

Nkọwa ngwaahịa

Ọnọdụ njem&ụkpụrụ mbupu akwadoro:
site n'ikuku, site n'oké osimiri ma ọ bụ site na awara awara

Ọnọdụ nchekwa:
E mechiri ya na nkụ, chekwaa na friza, n'okpuru -20 Celsius

Ọnụ ahịa kacha nta:
Mkparịta ụka

Asambodo:
COA, HPLC, GC, HNMR, Assay, Ọdịnaya Mmiri (KF), TLC dị

Ụdị okwu

N5-[[(2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl) sulfonyl] amino] iminomethyl] -N2-BOC-L-ornithine;
Nα-Boc-Nω- (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl) -L-arginine;
Nalpha-Boc-Nomega- (2,2,4,6,7-pentamethyl-2,3-dihydrobenzo [b]furan-5-sulfonyl) -L-arginine;
BOC-ARGININE(PBF)-OH;BOC-L-ARG(PBF)-OH;
BOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE

Nkwakọ ngwaahịa n'ime

A na-ejikarị ha ebu ntụ ntụ.Ha nwekwara ike igbochi anwụ na mmiri ime ihe ọjọọ.

mpụta mbukota

Katọn ahụ siri ike nwere ike ichekwa ngwaahịa gị ka ọ ghara ịdaba na mmiri.

Ngwa

Boc-Arg (Pbf) -OH bụ ihe nrụpụta arginine.
Bivalirudine, ọgwụ mgbochi sịntetik nke bụ nwa nwanne 20-peptide nke hirudin, ka akwadoro maka ire ere na United States na 2000. Ngwunye ahụ bụ ihe na-acha ọcha, ihe na-adịghị mma ma ọ bụ ihe siri ike amorphous.Bivarudine nwere ike jikọta kpọmkwem na saịtị thrombin catalytic na anion mpụga njikọ, ma gbochie ọrụ thrombin ozugbo, si otú a na-egbochi mmeghachi omume catalyzed na thrombin, na mmetụta ya na-agbanwe.A na-ejikarị Bivarudine eme ihe dị ka ọgwụ mgbochi ọbara maka ahọpụtara percutaneous coronary intervention (PCI) na ndị okenye.
Bivarudine bụ onye na-egbochi thrombin kpọmkwem, nke na-ejikọta kpọmkwem na saịtị catalytic na anion exo-binding saịtị nke thrombin n'efu yana na thrombus.Usoro njikọ dị n'etiti bivaludine na thrombin na-agbanwe agbanwe, na thrombin nwere ike weghachite ọrụ mbụ nke thrombin site na iji nwayọọ nwayọọ enzymolysis nke njikọ peptide n'etiti bivaludine Arg3-Pro4.
Nnyocha ọmụmụ vitro egosila na bivarudine nwere ike ọ bụghị naanị igbochi thrombin n'akụkụ, kamakwa na-egbochi njikọ nke thrombin na mkpụkọ ọbara na-ewepụghị ya site na ihe ndị platelet wepụtara.Ọ nwere ike ịgbatị oge prothrombin akụkụ (APTT), oge thrombin (TT), oge prothrombin (PT) na oge coagulation na-arụ ọrụ (ACT) nke plasma na-arụ ọrụ.Enwere mmekọrịta kwụ ọtọ na ntinye nke bivarudine, mana ma njikọ a dị na ngwa ụlọ ọgwụ amabeghị.
A kọwo n'akwụkwọ akụkọ na pharmacokinetics nke ndị ọrịa na-arịa ọrịa angioplasty percutaneous (PTCA) bụ ahịrị mgbe nchịkwa intravenous nke bivarudine gasịrị.Enyere onye ọrịa ahụ 1 mg / kg intravenously dị ka ibu ibu, na-esote ntinye IV ọzọ nke 2.5 mg / kg / hr maka awa 4, nke kwadoro na 12.3 ± 1.7 mg / ml na vivo.A na-ehichapụ Bivarudine na plasma site na renal hydrolysis na mmebi protease.Nchapụta ọkara ndụ nke ndị ọrịa nwere ọrụ gbasara akụrụ nkịtị bụ ihe dị ka nkeji iri abụọ na ise, na mkpochapụ ọkara ndụ nke ndị ọrịa nwere oke ụkọ gbasara akụrụ na-agbatịkwu.Ihe dị ka 25% nke bivarudine nwere ike wepụ ya site na dialysis wee kpochapụ site na hemodialysis.Ekwesịrị ileba anya na ACT na ndị ọrịa nwere nsogbu gbasara akụrụ.N'ime ndị ọrụ afọ ofufo ahụ siri ike, a na-ahụ mmetụta anticoagulant ozugbo mgbe nchịkwa intravenous nke bivarudine gasịrị, yana PT, ACT na APTT ogologo oge.Otu awa ma ọ bụ abụọ ka ewepụrụ, ACT laghachiri n'ọkwa nchịkwa tupu oge eruo.

ngwaahịa ndị metụtara ya

Cbz-Phe-Arg-OH	Boc-L-Arg-OH.HCl
Arg-Tyr-Oet	Boc-L-Arg-OH.HCl.H2O
HL-Arg-OH	Boc-D-Arg-OH•HCl•H2O
HD-Arg-OH	Boc-Arg (Cbz) -OH
DL-Arg-OH	Fmoc-L-Arg-OH
L-Arg-Ome.2Hcl	Fmoc-D-Arg-OH
D-Arg-Ome.2HCl	Fmoc-L-Arg(NO2)-OH
L-Arg(Pbf)-OH	Fmoc-L-Arg(Pbf) -OH
D-Arg(NO2)-OH/N-NO2-D-Arg	Fmoc-HoArg(Pbf) -OH
HL-Arg (NO2)-OH	Fmoc-Arg (Tos) -OH
HL-Arg (Tos) - OH	Fmoc-D-Arg(Tos) -OH
L-Arg-NH2	Fmoc-D-Arg(Pbf) -OH
Boc-L-Arg-OH	Cbz-Arg-OH
Boc-D-Arg (Pbf)	Cbz-D-Arg-OH
Boc-Arg-Oet	Cbz-L-Arg(Pbf)-OH
Boc-L-Arg-Ome	Cbz-D-Arg(pbf) .CHA
Boc-L-Arg(Tos) -OH	Cbz-D-Arg-Gly-OH
Boc-L-Arg(NO2)-OH	L-Arg (Pbf) -Asp
Fmoc-L-HomoArg-OH	L-Homoarg.hcl

Nke kacha elu

1. R&D ọrụ dị
2. Onye nrụpụta akwụkwọ ikike ISO, nkwa dị mma
3.A zuru oke nke ọrụ ntinye aka n'oge mmepụta
4.High ọnụ ahịa dị irè
5.Quality akwụkwọ ikike nyere maka arịrịọ ndị ahịa
6.Great after-sales service, ịnọgide na-enwe mmekọrịta chiri anya na ndị ahịa
7.Full akụ iji nyere aka belata ụgwọ mbupu
8.Free sample nyere iji lelee àgwà tupu ịkwụ ụgwọ ọ bụla
9.Payment okwu mkparita uka
Ndị ahịa 10.Assit na-emekọ ihe na China